Chief Executive Officer · Upstream Bio, Inc. (UPB)

E. Rand Sutherland

A named executive officer of Upstream Bio in every fiscal year CompBrief holds from FY2024 to FY2025. Every figure below is printed as the company filed it and cited to the filing it came from.

Velarion Intel: free for 3 days, no card →

Total disclosed compensation, FY2025

$4,302,100

FY2024: $9,108,953

1st of 3 named executive officers at Upstream Bio by FY2025 total.

3 named officers on file for Upstream Bio, FY2025

See an example →

What this number hides

The filing gives the total. Upstream Bio’s full Executive Compensation Report gives every award, the disclosed peer set and what the total leaves out — the pair adds the board’s.

Compensation figures as of the proxy filed April 16, 2026 (DEF 14A). Insider transactions since that proxy, current to 2026-11-06.

Free

Get E. Rand Sutherland’s full pay file as a PDF — free

More than this page: up to 10 years of E. Rand Sutherland’s pay history, a side-by-side peer comparison, and a one-page board summary — the whole file, yours now and by email.

Also free: The Pay Desk, the weekly executive pay briefing.

Or track E. Rand Sutherland and every company like it: Velarion Intel, free for 3 days, no card →

E. Rand Sutherland compensation by year

Upstream Bio Summary Compensation Table · all 2 fiscal years held
In US dollars, as Upstream Bio reports it. Most recent year shaded. Totals are the company’s disclosed totals.
ComponentFY2024FY2025
Salary$407,955$650,000
Bonus$0$0
Stock awards$0$0
Option awards$8,375,648$3,300,350
Non-equity incentive$315,000$341,250
Pension and deferred compensation$0$0
All other$10,350$10,500
Total$9,108,953$4,302,100

Each year as stated in that year's proxy. A dash means the company reported no figure in that column. Source: Upstream Bio, Inc. DEF 14A filed April 16, 2026, accession 0001193125-26-158966, and prior-year filings. Open the filing on EDGAR.

How this page was built: the Upstream Bio, Inc. filed document, accession 0001193125-26-158966. Every figure is read from that document and cited to the page and table it appears in. Filed April 16, 2026.

$9.1M
$4.3M
FY24
FY25
SalaryNon-equity incentiveOption awardsAll other

Equity holdings

unvested awards at FY2025 year-end
TypeUnvested unitsValue at year-endExercise price
Option505,578—$5.69
Option614,717—$6.59
Option395,834—$8.53

Per the Outstanding Equity Awards at Fiscal Year-End table in Upstream Bio, Inc.'s FY2025 proxy; value at the fiscal year-end close, as the company printed it.

Insider transactions since the last proxy

2 Form 4 lines since the FY2025 proxy (filed April 16, 2026)
current to 2026-11-06 · updated nightly
DateTransactionPlanSharesPriceHeld after
2026-09-16Sale—2,095$5.4968,717
2026-06-16Sale—2,095$6.1070,812

The 2 most recent of 2 lines, each as reported on the Form 4. "10b5-1" marks a trade the filing reports under a pre-arranged trading plan. View every Form 4 filing on EDGAR →

Upstream Bio’s named executive officers, FY2025

as the company reported each
Named executive officerRoleFY2025 total
E. Rand Sutherland · this pageChief Executive Officer$4,302,100
Michael Paul GrayChief Financial Officer and Chief Operating Officer$1,993,437
Aaron DeykinChief Medical Officer and Head of Research and Development$1,830,916

Board service

Upstream Bio board · FY2025

How this board is paid

Company policy: Upstream Bio pays directors a $40,000 cash retainer. As stated in Upstream Bio's FY2025 proxy.

The full Upstream Bio compensation record

free company brief

This page is one person within Upstream Bio's record. The company brief lists every named executive, each linking to their own page.

Compensation, the day it’s disclosed

The CompBrief Daily Digest lists the newest executive and director compensation disclosures as companies file them. Or order Upstream Bio's full Executive Compensation Report with peer benchmarking.

How this record is built

Every figure on this page is one figure from a public SEC filing, printed as the filing states it and cited to the document. Compensation totals are Upstream Bio's own disclosed totals, not summed by Velarion. Insider transactions are read from Form 4 filings and cover every line filed since the most recent proxy. Nothing is estimated by Velarion; where the company does not disclose a value the cell reads "—", and a section appears only where the company discloses the data. Corrections: records@velarion.ai.

Order UPB

Add the email the receipt and the PDF go to, then press the report you want. Each button opens its own card payment on Stripe.

Receipt, invoice, and report delivery. Guest checkout, no account required, secure payment by Stripe.

E. Rand Sutherland's compensation dossier