Velarion · Company Intelligence
Compensation Brief
Fiscal year 2025 · Filings through 2026-10-14

Summit Therapeutics (SMMT)

CEO Robert Duggan was paid $172,376 in fiscal year 2025, ↑ up 8.7% from fiscal year 2024 (SEC filing 0001599298-26-000029 ↗): executive and director compensation, incentive-plan design, equity activity, and governance — every figure in this brief is traceable to its exact location in the company’s SEC filing — the document, the section, the page, and the table, linked directly.

$249,127,782
Manmeet Soni total, FY2025
Chief Operating Officer, Chief Financial Officer and Director — highest-paid officer; CEO Robert Duggan: $172,376
—
CEO (Robert Duggan) pay percentile vs peers
489:1
CEO-to-median pay ratio
96.22%
Say-on-pay support, latest vote

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SMMT's next annual pay disclosure, estimated April 17, 2027.est. Filing ↗

01

Summary Compensation Table — fiscal year 2025

Named executive officerSalaryBonusStock awardsOption awardsNon-equity incentivePension / NQDCAll otherTotal
Manmeet Soni$616,500$388,395$0$248,101,887$0$0$21,000$249,127,782
Chief Operating Officer, Chief Financial Officer and Director
Mahkam Zanganeh616,500388,3950245,021,3840021,000246,047,279
Co-Chief Executive Officer, President and Director
Robert Duggan000000172,376172,376
Co-Chief Executive Officer and Chairman of the Board of Directors

A dash means the company reported no figure in that column; 0 means it reported zero. Figures are as printed in the filing, without adjustment.

Three-year trend — total compensation per named executive

Named executive officerFY2025 totalFY2024 totalFY2023 totalΔ FY2024→2025
Manmeet Soni$249,127,782$4,772,489$23,613,339↑ +244,355,293
Mahkam Zanganeh246,047,2791,161,02120,562,924↑ +244,886,258
Robert Duggan172,376158,6130↑ +13,763

Prior-year totals as disclosed in the corresponding proxy; deltas are computed values with the derivation shown in the register.

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Companies that benchmark against SMMT
7 companies name SMMT as a compensation peer

The list of companies that name SMMT as a peer is temporarily unavailable — recheck shortly.

01b

Executives — the named officers

One page per officer: the same table above, read for one person at a time — his own figure and every fiscal year the register holds.

ExecutiveRoleFY2025 total
Robert DugganCEO$172,376
Mahkam ZanganehCEO$246,047,279
Manmeet SoniCFO$249,127,782
01c

Board of directors

One page per director: the seat, the committees and the fee table, read for one person at a time.

DirectorRoleFY2025 total
Alessandra CesanoIndependent Director$640,181
Jeff HuberIndependent Director$649,186
Kenneth A. ClarkLead Independent Director$835,697
Mostafa RonaghiIndependent Director$625,486
Robert BoothIndependent Director$672,773
Yu (Michelle) XiaDirector$649,996
02

Equity transactions since the proxy statement was filed

Every insider equity transaction reported on Form 4 after the 2025 proxy statement — acquisitions, dispositions, exercises, and withholdings — and therefore not reflected in any table in that document.

InsiderRoleTransaction dateCodeSharesPriceValueSecuritySource
Robert W. DugganDirector2026-06-04A100,000$15$1,460,000Common, indirectForm 4 ↗
Manmeet SoniDirector2026-06-04A25,00014360,750CommonForm 4 ↗
Manmeet SoniDirector2026-06-04A25,00014361,500CommonForm 4 ↗
Mahkam ZanganehDirector2026-06-04A100,000151,460,000Common, indirectForm 4 ↗
Mahkam ZanganehDirector2026-06-12A3,810,0001349,987,200Common, indirectForm 4 ↗
Robert W. DugganDirector2026-06-12A3,810,0001349,987,200CommonForm 4 ↗
Bhaskar AnandChief Accounting Officer2026-10-08A100,00000CommonForm 4 ↗

Transaction codes per Form 4: A acquisition · S open-market sale · F tax withholding · M option exercise · G gift. Value = shares × price as reported. Dividend-equivalent and fractional-share accrual rows (derivative Class A, under $10,000 and under 2,000 shares) are aggregated per date; every row appears in full below.

04

Outstanding equity awards at fiscal year-end 2025

ExecutiveAwardShares unvestedExercise priceMarket value unvested
Manmeet SoniOption3,732,4001.68—
Mahkam ZanganehOption346,5801.06—
Mahkam ZanganehOption133,3001.29—
Mahkam ZanganehOption3,196,0531.68—
Mahkam ZanganehOption5,994,0991.68—
Manmeet SoniOption7,000,0001.68—
Manmeet SoniOption825,0003.85—
05

Incentive-plan design — the Compensation Discussion & Analysis

We seek to ensure that the total compensation paid to our NEOs is reasonable and competitive. Compensation of our NEOs is structured around the achievement of individual performance, annual Company objectives and key results (“OKRs”) and long-term business objectives.

CEO STI target (% of salary)—
CEO LTI target (% of salary)—
Independent consultant—
Clawback policytrue
Anti-hedgingtrue
Anti-pledgingfalse
06

Say-on-pay — recent advisory votes

Meeting yearMeeting dateForAgainstAbstainSupportOutcome
20262026-06-10622,624,32824,445,791101,38396.22%Passed
20252025-06-12607,320,35316,607,648177,55697.34%Passed
20242024-06-14604,242,48215,872,371879,80197.44%Passed
20212021-06-1661,902,91265,33597,47999.89%Passed

Rows are labeled by annual-meeting year, with the meeting date beside each; the vote held in a given year acts on the prior fiscal year's compensation.

Say-on-pay — history, company's computation

Meeting yearMeeting dateApproval — company's computation
20262026-06-1096.22%a
20252025-06-1297.34%b
20242024-06-1497.44%c

a. Approved under the standard stated in the filing — “If you ABSTAIN from voting on this proposal, your abstention will not be counted as a vote cast on Proposal 3 and will have no effect on the outcome of the proposal.”.

b. Approved under the standard stated in the filing — “If you ABSTAIN from voting on this proposal, your abstention will not be counted as a vote cast on Proposal 3 and will have no effect on the outcome of the proposal.”.

c. Voting standard not stated in the filing.

Approval percentages are the company's own reported computations under its own stated standard, not recomputed by Velarion. Where a company does not state a standard, none is assumed.

07

CEO pay ratio

Ratio (CEO : median employee)489 : 1
CEO total compensation$246,047,279
Median employee compensation$503,340
08

Director compensation — fiscal year 2025

DirectorCash feesStock awardsOption awardsNon-equity incentiveAll otherTotal
Kenneth A. ClarkIndependent · Lead Independent Director · Compensation (Chair) · Nominating and Corporate Governance (Chair)$0$0$835,697—$0$835,697
Robert BoothIndependent · Audit · Nominating and Corporate Governance00672,773—0672,773
Yu (Michelle) XiaNot independent00649,996—0649,996
Jeff HuberIndependent · Audit (Chair)86,6000562,586—0649,186
Alessandra CesanoIndependent · Nominating and Corporate Governance28,2000611,981—0640,181
Mostafa RonaghiIndependent · Audit · Compensation62,9000562,586—0625,486
Manmeet SoniEmployee director000—00
Robert W. DugganEmployee director · Board Chair000—00
Mahkam ZanganehEmployee director000—00
09

Board fee structure and ownership guideline

Annual cash retainer$49,900
Annual equity retainer$35,000
Per board meeting fee—
Committee chair fees (audit / comp / nom-gov)36,700 / 13,000 / 13,000
Stock ownership guideline—
09b

Total cost of the board

ComponentFY2025
Cash retainers and fees$177,700
Equity awards (grant-date value)$0
All other compensation$0
Total cost of the board$177,700

Computed as the sum of the director compensation table rows above; inputs and formula shown in the register.

10b

Chief executive pay against the peer group

Most recent fiscal-year chief executive compensation at each disclosed peer, taken from that company's own proxy statement.

RankCompanyFYChief executiveSalaryStock awardsOption awardsNon-equity incentiveTotal
1Summit Therapeutics2025Robert Duggan$0$0$0$0$172,376

Each peer's compensation is from its most recently filed proxy; fiscal years differ by company. Each peer's figures come from its own filings; the subject company is highlighted. Peers whose chief executive compensation is outside our coverage universe are stated as such, never left blank.

10d

Frequently asked questions

Who was the highest-paid executive at Summit Therapeutics in fiscal 2025?
As disclosed, Manmeet Soni (Chief Operating Officer, Chief Financial Officer and Director) was the highest-paid executive at Summit Therapeutics in fiscal 2025, with total compensation of $249,127,782.
What is Summit Therapeutics's CEO-to-median employee pay ratio?
As disclosed, Summit Therapeutics's CEO-to-median employee pay ratio was 489:1.
How did shareholders vote on Summit Therapeutics's executive compensation?
As disclosed, 96.22% of shareholders supported Summit Therapeutics's executive compensation in the latest say-on-pay vote.
How much does Summit Therapeutics spend in total on board compensation for fiscal 2025?
As disclosed, Summit Therapeutics reported total board compensation of $177,700 for fiscal 2025.

Answers are drawn only from the figures disclosed in this brief and cited to their location in the source filing. Where a figure required for an answer is not disclosed, that is stated rather than estimated.

11

Source register

Each figure's location is given both for the eye (section · page · table · row · column) and for a script (table/row/column index and exact character span in the filed document). Any figure can be independently confirmed against the source.

#SupportsDocumentFiledAccessionLocation in document
1Section 01, Manmeet SoniDEF 14A2026-04-170001599298-26-000029Section “Executive Compensation”. As printed: 249,127,782. Filing ↗machine: r10 · c21 · span 391802–391813
2Section 01, Mahkam ZanganehDEF 14A2026-04-170001599298-26-000029Section “Executive Compensation”. As printed: 246,047,279. Filing ↗machine: r6 · c21 · span 385284–385295
3Section 01, Robert DugganDEF 14A2026-04-170001599298-26-000029Section “Executive Compensation”. As printed: 172,376. Filing ↗machine: r2 · c21 · span 378348–378355
4Section 07, pay ratioDEF 14A2026-04-170001599298-26-000029Section “CEO Pay Ratio”. As printed: 489 : 1. Filing ↗machine: span 499557–499560
5Section 08, Kenneth A. ClarkDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 835,697. Filing ↗machine: span 297922–298190
6Section 08, Robert BoothDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 672,773. Filing ↗machine: span 299323–299565
7Section 08, Yu (Michelle) XiaDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 649,996. Filing ↗machine: span 301915–302157
8Section 08, Jeff HuberDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 649,186. Filing ↗machine: span 304832–305074
9Section 08, Alessandra CesanoDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 640,181. Filing ↗machine: span 300959–301201
10Section 08, Mostafa RonaghiDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 625,486. Filing ↗machine: span 303549–303791
11Section 08, Manmeet SoniDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 0. Filing ↗
12Section 08, Robert W. DugganDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 0. Filing ↗
13Section 08, Mahkam ZanganehDEF 14A2026-04-170001599298-26-000029Section “Director Compensation”. As printed: 0. Filing ↗
14Section 02, Robert W. Duggan 2026-06-04Form 42026-06-040001055919-26-000005Insider equity transaction reported since the proxy statement. Filing ↗
15Section 02, Manmeet Soni 2026-06-04Form 42026-06-040001569769-26-000004Insider equity transaction reported since the proxy statement. Filing ↗
16Section 02, Manmeet Soni 2026-06-04Form 42026-06-040001569769-26-000004Insider equity transaction reported since the proxy statement. Filing ↗
17Section 02, Mahkam Zanganeh 2026-06-04Form 42026-06-040001507650-26-000005Insider equity transaction reported since the proxy statement. Filing ↗
18Section 02, Mahkam Zanganeh 2026-06-12Form 42026-06-120001507650-26-000007Insider equity transaction reported since the proxy statement. Filing ↗
19Section 02, Robert W. Duggan 2026-06-12Form 42026-06-120001055919-26-000007Insider equity transaction reported since the proxy statement. Filing ↗
20Section 02, Bhaskar Anand 2026-10-08Form 42026-10-140001890784-26-000006Insider equity transaction reported since the proxy statement. Filing ↗
21Section 06, 2026 voteForm 8-K2026-06-120001599298-26-000054Item 5.07 · say-on-pay result. As reported: 96.22% (votes for as printed: 622,624,328). Filing ↗
22Section 06, 2025 voteForm 8-K2025-06-170001599298-25-000116Item 5.07 · say-on-pay result. As reported: 97.34% (votes for as printed: 607,320,353). Filing ↗
23Section 06, 2024 voteForm 8-K2024-06-170001193125-24-162715Item 5.07 · say-on-pay result. As reported: 97.44% (votes for as printed: 604,242,482). Filing ↗
24Section 01 trend, Δ column (computed)Computed——Δ = current-FY total − prior-FY total per named officer.machine: formula: Δ = FY(n) − FY(n−1)
25Section 09b board cost (computed)Computed——Cash 177,700 + equity 0 + all other 0 = 177,700, summed across the director compensation table rows.machine: formula: Σ = 177,700
26Summit Therapeutics (subject), Section 10b CEO totalDEF 14A2026-04-170001599298-26-000029CEO total compensation as printed in Summit Therapeutics's own proxy. As printed: 172,376. Filing ↗machine: r2 · c21 · span 378348–378355

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