Velarion · Company Intelligence
Compensation Brief
Fiscal year 2025 · Filings through 2026-07-28

OPKO HEALTH, INC. (OPK)

CEO Phillip Frost was paid $1,854,000 in fiscal year 2025, ↓ down 14.3% from fiscal year 2024 (SEC filing 0001193125-26-197120 ↗): executive and director compensation, incentive-plan design, equity activity, and governance — every figure in this brief is traceable to its exact location in the company’s SEC filing — the document, the section, the page, and the table, linked directly.

$1,854,000 ↓
Phillip Frost total, FY2025
—
CEO pay percentile vs peers
42:1
CEO-to-median pay ratio
96.23%
Say-on-pay support, latest vote

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OPK's next annual pay disclosure, estimated April 30, 2027.est. Filing ↗

01

Summary Compensation Table — fiscal year 2025

Named executive officerSalaryBonusStock awardsOption awardsNon-equity incentivePension / NQDCAll otherTotal
Phillip Frost$960,000$480,000$0$400,000$0$0$14,000$1,854,000
Chief Executive Officer
Jane Hsiao900,000450,0000400,0000014,0001,764,000
Chief Technical Officer
Elias Zerhouni900,000450,0000400,0000014,0001,764,000
President
Steven Rubin810,000400,0000350,0000014,0001,574,000
Executive Vice President-Administration
Adam Logal700,000475,0000350,0000014,0001,539,000
Senior Vice President and Chief Financial Officer

A dash means the company reported no figure in that column; 0 means it reported zero. Figures are as printed in the filing, without adjustment.

Three-year trend — total compensation per named executive

Named executive officerFY2025 totalFY2024 totalFY2023 totalΔ FY2024→2025
Phillip Frost$1,854,000$2,163,800$2,277,200↓ −309,800
Jane Hsiao1,764,0002,073,8002,187,200↓ −309,800
Elias Zerhouni1,764,0002,073,8002,187,200↓ −309,800
Steven Rubin1,574,0001,845,0501,944,200↓ −271,050
Adam Logal1,539,0001,810,0501,809,200↓ −271,050

Prior-year totals as disclosed in the corresponding proxy; deltas are computed values with the derivation shown in the register.

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$1,854,000 Phillip Frost total, FY2025

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Data as of July 28, 2026 · Source: 0001193125-26-197120 · Velarion Executive Compensation Database, deposited on Zenodo (doi:10.5281/zenodo.22283855).

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01b

Executives — the named officers

One page per officer: the same table above, read for one person at a time — his own figure and every fiscal year the register holds.

ExecutiveRoleFY2025 total
Adam LogalCFO$1,539,000
Elias ZerhouniPresident$1,764,000
Phillip FrostCEO$1,854,000
Jane HsiaoExecutive$1,764,000
Steven RubinEVP$1,574,000
01c

Board of directors

One page per director: the seat, the committees and the fee table, read for one person at a time.

DirectorRoleFY2025 total
Alice Lin-Tsing Yu, M.D., Ph.DIndependent Director$59,100
Gary J. Nabel, M.D., Ph.DDirector—
John A. PaganelliIndependent Director$81,600
Prem A. Lachman, M.DIndependent Director$89,100
Richard C. Pfenniger, JrLead Independent Director—
Richard M. Krasno, Ph.DFormer director (through FY2025)$89,100
Roger J. Medel, M.DIndependent Director$66,600
Subbarao V. Uppaluri, Ph.DIndependent Director—
02

Equity transactions since the proxy statement was filed

Every insider equity transaction reported on Form 4 after the 2025 proxy statement — acquisitions, dispositions, exercises, and withholdings — and therefore not reflected in any table in that document.

InsiderRoleTransaction dateCodeSharesPriceValueSecuritySource
John A. PaganelliDirector2026-06-18A30,000$0$0Derivative, Class A CommonForm 4 ↗
Roger Medel MdDirector2026-06-18A30,00000Derivative, Class A CommonForm 4 ↗
Prem A. LachmanDirector2026-06-18A30,00000Derivative, Class A CommonForm 4 ↗
Alice Lin-Tsing YuDirector2026-06-18A30,00000Derivative, Class A CommonForm 4 ↗
Richard C. Pfenniger JrDirector2026-06-18A60,00000Derivative, Class A CommonForm 4 ↗
Subbarao Uppaluri VDirector2026-06-18A80,00000Derivative, Class A CommonForm 4 ↗
Adam LogalSr. Vice President, CFO2026-07-24D53,266164,985CommonForm 4 ↗
Steven D. RubinDirector2026-07-24D53,266164,985CommonForm 4 ↗

Transaction codes per Form 4: A acquisition · S open-market sale · F tax withholding · M option exercise · G gift. Value = shares × price as reported. Dividend-equivalent and fractional-share accrual rows (derivative Class A, under $10,000 and under 2,000 shares) are aggregated per date; every row appears in full below.

03

Grants of plan-based awards — fiscal year 2025

ExecutiveAwardGrant dateThresholdTargetGrantedMaximumGrant-date fair value
Elias ZerhouniOPTION2025-05-27——500,000—$400,000
Jane HsiaoOPTION2025-05-27——500,000—400,000
Phillip FrostOPTION2025-05-27——500,000—400,000
Steven RubinOPTION2025-05-27——437,500—350,000
Adam LogalOPTION2025-05-27——437,500—350,000
03b

Vehicle mix — grant-date fair value by award type

Named executive officerTime-vested (RSU)Performance-vested (PSU)Options / SARs% performance-vested
Elias Zerhouni$0$0$400,0000.0%
Jane Hsiao00400,0000.0%
Phillip Frost00400,0000.0%
Steven Rubin00350,0000.0%
Adam Logal00350,0000.0%

% performance-vested = PSU grant-date fair value ÷ (RSU + PSU + Options), a computed value with the derivation shown in the register.

04

Outstanding equity awards at fiscal year-end 2025

ExecutiveAwardShares unvestedExercise priceMarket value unvested
Steven RubinOption437,5001.31—
Steven RubinOption350,0001.58—
Phillip FrostRSU500,000—630,000
Jane HsiaoRSU500,000—630,000
Elias ZerhouniRSU630,000—630,000
Steven RubinRSU437,500—551,250
Adam LogalRSU437,500—551,250
Phillip FrostOption350,0002.47—
Phillip FrostOption400,0001.58—
Phillip FrostOption500,0001.31—
Jane HsiaoOption400,0001.58—
Jane HsiaoOption500,0001.31—
Elias ZerhouniOption400,0001.58—
Elias ZerhouniOption500,0001.31—
Adam LogalOption350,0001.58—
Adam LogalOption437,5001.31—
05

Incentive-plan design — the Compensation Discussion & Analysis

Our compensation philosophy is to attract and retain talented and dedicated executives who will work to achieve our desired business direction, strategy, and performance. The primary goals are to be competitive in the marketplace, tie annual and long-term cash and equity incentives to the achievement of specified performance objectives that will result in increased stockholder value, and to be cost-effective.

CEO STI target (% of salary)—
CEO LTI target (% of salary)—
Independent consultant—
Clawback policytrue
Anti-hedgingtrue
Anti-pledgingtrue
06

Say-on-pay — recent advisory votes

Meeting yearMeeting dateForAgainstAbstainSupportOutcome
20262026-06-18446,238,17017,487,326413,66796.23%Passed
20252025-04-23439,260,12510,995,027513,04797.56%Passed
20242024-03-28431,121,61313,954,1921,522,26596.86%Passed
20232023-06-22437,636,65614,823,8031,085,00396.72%Passed
20222022-07-14402,336,41228,153,806936,56693.46%Passed
20212021-06-24407,430,45422,479,7031,744,34794.77%Passed

Rows are labeled by annual-meeting year, with the meeting date beside each; the vote held in a given year acts on the prior fiscal year's compensation.

Say-on-pay — history, company's computation

Meeting yearMeeting dateApproval — company's computation
20262026-06-1896.23%a
20252025-04-2397.56%b
20242024-03-2896.86%c

a. Voting standard not stated in the filing.

b. Approved under the standard stated in the filing — “Shares of our stock represented by proxies that reflect abstentions will be counted for the purpose of determining the existence of a quorum at the Annual Meeting, but will have no effect on the election of directors, the Say on Pay proposal, or the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.”.

c. Approved under the standard stated in the filing — “Shares of our stock represented by proxies that reflect abstentions will be counted for the purpose of determining the existence of a quorum at the Annual Meeting, but will have no effect on the approval of the election of directors, the Charter Amendment proposal, the Say on Pay proposal, or the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024 .”.

Approval percentages are the company's own reported computations under its own stated standard, not recomputed by Velarion. Where a company does not state a standard, none is assumed.

07

CEO pay ratio

Ratio (CEO : median employee)42 : 1
CEO total compensation$1,854,000
Median employee compensation$44,252
08

Director compensation — fiscal year 2025

DirectorCash feesStock awardsOption awardsNon-equity incentiveAll otherTotal
Richard C. Pfenniger JrIndependent · Lead Independent Director · Succession (Chair)$70,000$0$58,200$0$0$128,200
Richard M. Krasno, Ph.DIndependent · Departed during FY60,000029,1000089,100
Prem A. Lachman, M.DIndependent · Audit · Compensation · Corporate Governance and Nominating60,000029,1000089,100
John A. PaganelliIndependent · Audit · Corporate Governance and Nominating (Chair) · Independent Investment52,500029,1000081,600
Roger J. Medel, M.DIndependent · Compensation · Corporate Governance and Nominating37,500029,1000066,600
Alice Lin-Tsing Yu, M.D., Ph.DIndependent30,000029,1000059,100
Elias A. Zerhouni, M.DEmployee director—————0
Gary J. Nabel, M.D., Ph.DEmployee director—————0
Phillip Frost, M.DEmployee director · Board Chair—————0
Steven D. RubinEmployee director—————0
Jane H. Hsiao, Ph.D., MBAEmployee director—————0
Subbarao V. Uppaluri, Ph.DIndependent——————
09

Board fee structure and ownership guideline

Annual cash retainer$30,000
Annual equity retainer—
Per board meeting fee—
Committee chair fees (audit / comp / nom-gov)7,500 / 7,500 / 7,500
Stock ownership guideline—
09b

Total cost of the board

ComponentFY2025
Cash retainers and fees$310,000
Equity awards (grant-date value)$0
All other compensation$0
Total cost of the board$310,000

Computed as the sum of the director compensation table rows above; inputs and formula shown in the register.

10b

Chief executive pay against the peer group

Most recent fiscal-year chief executive compensation at each disclosed peer, taken from that company's own proxy statement.

RankCompanyFYChief executiveSalaryStock awardsOption awardsNon-equity incentiveTotal
1OPKO HEALTH, INC.2025Phillip Frost$960,000$0$400,000$0$1,854,000

Each peer's compensation is from its most recently filed proxy; fiscal years differ by company. Each peer's figures come from its own filings; the subject company is highlighted. Peers whose chief executive compensation is outside our coverage universe are stated as such, never left blank.

10d

Frequently asked questions

Who was the highest-paid executive at OPKO HEALTH, INC. in fiscal 2025?
As disclosed, Phillip Frost (Chief Executive Officer) was the highest-paid executive at OPKO HEALTH, INC. in fiscal 2025, with total compensation of $1,854,000.
What is OPKO HEALTH, INC.'s CEO-to-median employee pay ratio?
As disclosed, OPKO HEALTH, INC.'s CEO-to-median employee pay ratio was 42:1.
How did shareholders vote on OPKO HEALTH, INC.'s executive compensation?
As disclosed, 96.23% of shareholders supported OPKO HEALTH, INC.'s executive compensation in the latest say-on-pay vote.
How much does OPKO HEALTH, INC. spend in total on board compensation for fiscal 2025?
As disclosed, OPKO HEALTH, INC. reported total board compensation of $310,000 for fiscal 2025.

Answers are drawn only from the figures disclosed in this brief and cited to their location in the source filing. Where a figure required for an answer is not disclosed, that is stated rather than estimated.

11

Source register

Each figure's location is given both for the eye (section · page · table · row · column) and for a script (table/row/column index and exact character span in the filed document). Any figure can be independently confirmed against the source.

#SupportsDocumentFiledAccessionLocation in document
1Section 01, Phillip FrostDEF 14A2026-04-300001193125-26-197120Section “Executive Compensation”. As printed: 1,854,000. Filing ↗machine: r4 · c25 · span 941666–941675
2Section 01, Jane HsiaoDEF 14A2026-04-300001193125-26-197120Section “Executive Compensation”. As printed: 1,764,000. Filing ↗machine: r8 · c25 · span 977235–977244
3Section 01, Elias ZerhouniDEF 14A2026-04-300001193125-26-197120Section “Executive Compensation”. As printed: 1,764,000. Filing ↗machine: r12 · c25 · span 1012777–1012786
4Section 01, Steven RubinDEF 14A2026-04-300001193125-26-197120Section “Executive Compensation”. As printed: 1,574,000. Filing ↗machine: r16 · c25 · span 1048297–1048306
5Section 01, Adam LogalDEF 14A2026-04-300001193125-26-197120Section “Executive Compensation”. As printed: 1,539,000. Filing ↗machine: r20 · c25 · span 1083868–1083877
6Section 03, Elias Zerhouni OPTIONDEF 14A2026-04-300001193125-26-197120Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r12 · c17 · span 1010026–1010033
7Section 03, Jane Hsiao OPTIONDEF 14A2026-04-300001193125-26-197120Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r8 · c17 · span 974484–974491
8Section 03, Phillip Frost OPTIONDEF 14A2026-04-300001193125-26-197120Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r4 · c17 · span 938915–938922
9Section 03, Steven Rubin OPTIONDEF 14A2026-04-300001193125-26-197120Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r16 · c17 · span 1045546–1045553
10Section 03, Adam Logal OPTIONDEF 14A2026-04-300001193125-26-197120Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r20 · c17 · span 1081117–1081124
11Section 07, pay ratioDEF 14A2026-04-300001193125-26-197120Section “CEO Pay Ratio”. As printed: 42 : 1. Filing ↗
12Section 08, Richard C. Pfenniger JrDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 128,200. Filing ↗machine: span 623922–624131
13Section 08, Richard M. Krasno, Ph.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 89,100. Filing ↗machine: span 593553–593761
14Section 08, Prem A. Lachman, M.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 89,100. Filing ↗machine: span 603675–603883
15Section 08, John A. PaganelliDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 81,600. Filing ↗machine: span 634041–634249
16Section 08, Roger J. Medel, M.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 66,600. Filing ↗machine: span 613796–614004
17Section 08, Alice Lin-Tsing Yu, M.D., Ph.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 59,100. Filing ↗machine: span 644173–644381
18Section 08, Elias A. Zerhouni, M.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 0. Filing ↗
19Section 08, Gary J. Nabel, M.D., Ph.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 0. Filing ↗
20Section 08, Phillip Frost, M.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 0. Filing ↗
21Section 08, Steven D. RubinDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 0. Filing ↗
22Section 08, Jane H. Hsiao, Ph.D., MBADEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: 0. Filing ↗
23Section 08, Subbarao V. Uppaluri, Ph.DDEF 14A2026-04-300001193125-26-197120Section “Director Compensation”. As printed: —. Filing ↗
24Section 02, John A. Paganelli 2026-06-18Form 42026-06-220001193125-26-277744Insider equity transaction reported since the proxy statement. Filing ↗
25Section 02, Roger Medel Md 2026-06-18Form 42026-06-220001193125-26-277747Insider equity transaction reported since the proxy statement. Filing ↗
26Section 02, Prem A. Lachman 2026-06-18Form 42026-06-220001193125-26-277749Insider equity transaction reported since the proxy statement. Filing ↗
27Section 02, Alice Lin-Tsing Yu 2026-06-18Form 42026-06-220001193125-26-277731Insider equity transaction reported since the proxy statement. Filing ↗
28Section 02, Richard C. Pfenniger Jr 2026-06-18Form 42026-06-220001193125-26-277740Insider equity transaction reported since the proxy statement. Filing ↗
29Section 02, Subbarao Uppaluri V 2026-06-18Form 42026-06-220001193125-26-277734Insider equity transaction reported since the proxy statement. Filing ↗
30Section 02, Adam Logal 2026-07-24Form 42026-07-280001193125-26-321055Insider equity transaction reported since the proxy statement. Filing ↗
31Section 02, Steven D. Rubin 2026-07-24Form 42026-07-280001193125-26-321041Insider equity transaction reported since the proxy statement. Filing ↗
32Section 06, 2026 voteForm 8-K2026-06-180001193125-26-275818Item 5.07 · say-on-pay result. As reported: 96.23% (votes for as printed: 446,238,170). Filing ↗
33Section 06, 2025 voteForm 8-K2025-04-230001437749-25-012806Item 5.07 · say-on-pay result. As reported: 97.56% (votes for as printed: 439,260,125). Filing ↗
34Section 06, 2024 voteForm 8-K2024-03-290001437749-24-010069Item 5.07 · say-on-pay result. As reported: 96.86% (votes for as printed: 431,121,613.12). Filing ↗
35Section 01 trend, Δ column (computed)Computed——Δ = current-FY total − prior-FY total per named officer.machine: formula: Δ = FY(n) − FY(n−1)
36Section 03b vehicle mix (computed)Computed——RSU / PSU / Options grant-date fair values summed per officer from the grants table; % performance-vested = PSU ÷ (RSU+PSU+Options).machine: formula: sums + PSU ratio
37Section 09b board cost (computed)Computed——Cash 310,000 + equity 0 + all other 0 = 310,000, summed across the director compensation table rows.machine: formula: Σ = 310,000
38OPKO HEALTH, INC. (subject), Section 10b CEO totalDEF 14A2026-04-300001193125-26-197120CEO total compensation as printed in OPKO HEALTH, INC.'s own proxy. As printed: 1,854,000. Filing ↗machine: r4 · c25 · span 941666–941675

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