Fiscal year 2025 executive and director compensation, incentive-plan design, equity activity, and governance — every figure in this brief is traceable to its exact location in the company’s SEC filing — the document, the section, the page, and the table, linked directly.
Each company listed discloses OPK in its own benchmarking peer group, as disclosed in each company's most recent proxy statement within the last two proxy seasons. Two companies are therefore absent by design: one that named OPK in an earlier year and no longer does, and one whose own most recent disclosure is older than the last two seasons.
| Named executive officer | Salary | Bonus | Stock awards | Option awards | Non-equity incentive | Pension / NQDC | All other | Total |
|---|---|---|---|---|---|---|---|---|
| Phillip Frost | $960,000 | $480,000 | $0 | $400,000 | — | — | $14,000 | $1,854,000 |
| Chief Executive Officer | ||||||||
| Elias Zerhouni | 900,000 | 450,000 | 0 | 400,000 | — | — | 14,000 | 1,764,000 |
| Vice Chairman and President | ||||||||
| Jane Hsiao | 900,000 | 450,000 | 0 | 400,000 | — | — | 14,000 | 1,764,000 |
| Vice-Chairman and Chief Technical Officer | ||||||||
| Steven Rubin | 810,000 | 400,000 | 0 | 350,000 | — | — | 14,000 | 1,574,000 |
| Executive Vice President – Administration | ||||||||
| Adam Logal | 700,000 | 475,000 | 0 | 350,000 | — | — | 14,000 | 1,539,000 |
| Senior Vice President, Chief Financial Officer, Chief Accounting Officer, and Treasurer | ||||||||
A dash means the company reported no figure in that column; 0 means it reported zero. Figures are as printed in the filing, without adjustment.
| Named executive officer | FY2025 total | FY2024 total | FY2023 total | Δ FY2024→2025 |
|---|---|---|---|---|
| Phillip Frost | $1,854,000 | $2,163,800 | $2,277,200 | −309,800 |
| Elias Zerhouni | 1,764,000 | 2,073,800 | 2,187,200 | −309,800 |
| Jane Hsiao | 1,764,000 | 2,073,800 | 2,187,200 | −309,800 |
| Steven Rubin | 1,574,000 | 1,845,050 | 1,944,200 | −271,050 |
| Adam Logal | 1,539,000 | 1,810,050 | 1,809,200 | −271,050 |
Prior-year totals as disclosed in the corresponding proxy; deltas are computed values with the derivation shown in the register.
Every insider equity transaction reported on Form 4 after the 2025 proxy statement — acquisitions, dispositions, exercises, and withholdings — and therefore not reflected in any table in that document.
| Insider | Role | Transaction date | Code | Shares | Price | Value | Security | Source |
|---|---|---|---|---|---|---|---|---|
| John A. Paganelli | Director | 2026-06-18 | A | 30,000 | $0 | $0 | Derivative, Class A Common | Form 4 ↗ |
| Alice Lin-Tsing Yu | Director | 2026-06-18 | A | 30,000 | 0 | 0 | Derivative, Class A Common | Form 4 ↗ |
| Richard C. Pfenniger Jr | Director | 2026-06-18 | A | 60,000 | 0 | 0 | Derivative, Class A Common | Form 4 ↗ |
| Subbarao Uppaluri V | Director | 2026-06-18 | A | 80,000 | 0 | 0 | Derivative, Class A Common | Form 4 ↗ |
| Roger Medel Md | Director | 2026-06-18 | A | 30,000 | 0 | 0 | Derivative, Class A Common | Form 4 ↗ |
| Prem A. Lachman | Director | 2026-06-18 | A | 30,000 | 0 | 0 | Derivative, Class A Common | Form 4 ↗ |
| Adam Logal | Sr. Vice President, CFO | 2026-07-24 | D | 53,266 | 1 | 64,985 | Common | Form 4 ↗ |
| Steven D. Rubin | Director | 2026-07-24 | D | 53,266 | 1 | 64,985 | Common | Form 4 ↗ |
Transaction codes per Form 4: A acquisition · S open-market sale · F tax withholding · M option exercise · G gift. Value = shares × price as reported. Dividend-equivalent and fractional-share accrual rows (derivative Class A, under $10,000 and under 2,000 shares) are aggregated per date; every row appears in full below.
| Executive | Award | Grant date | Threshold | Target | Granted | Maximum | Grant-date fair value |
|---|---|---|---|---|---|---|---|
| Phillip Frost | OPTION | 2025-05-27 | — | — | 500,000 | — | $400,000 |
| Elias Zerhouni | OPTION | 2025-05-27 | — | — | 500,000 | — | 400,000 |
| Steven Rubin | OPTION | 2025-05-27 | — | — | 437,500 | — | 350,000 |
| Adam Logal | OPTION | 2025-05-27 | — | — | 437,500 | — | 350,000 |
| Jane Hsiao | OPTION | 2025-05-27 | — | — | 500,000 | — | 400,000 |
| Named executive officer | Time-vested (RSU) | Performance-vested (PSU) | Options / SARs | % performance-vested |
|---|---|---|---|---|
| Phillip Frost | $0 | $0 | $400,000 | 0.0% |
| Elias Zerhouni | 0 | 0 | 400,000 | 0.0% |
| Steven Rubin | 0 | 0 | 350,000 | 0.0% |
| Adam Logal | 0 | 0 | 350,000 | 0.0% |
| Jane Hsiao | 0 | 0 | 400,000 | 0.0% |
% performance-vested = PSU grant-date fair value ÷ (RSU + PSU + Options), a computed value with the derivation shown in the register.
| Executive | Award | Shares unvested | Exercise price | Market value unvested |
|---|---|---|---|---|
| Phillip Frost | Option | 350,000 | 2.47 | — |
| Elias Zerhouni | Option | 400,000 | 1.58 | — |
| Steven Rubin | RSU | 437,500 | — | 551,250 |
| Phillip Frost | Option | 500,000 | 1.31 | — |
| Steven Rubin | Option | 350,000 | 1.58 | — |
| Adam Logal | Option | 350,000 | 1.58 | — |
| Elias Zerhouni | Option | 500,000 | 1.31 | — |
| Adam Logal | Option | 437,500 | 1.31 | — |
| Phillip Frost | Option | 400,000 | 1.58 | — |
| Jane Hsiao | Option | 500,000 | 1.31 | — |
| Jane Hsiao | RSU | 500,000 | — | 630,000 |
| Elias Zerhouni | RSU | 630,000 | — | 630,000 |
| Phillip Frost | RSU | 500,000 | — | 630,000 |
| Adam Logal | RSU | 437,500 | — | 551,250 |
| Jane Hsiao | Option | 400,000 | 1.58 | — |
| Steven Rubin | Option | 437,500 | 1.31 | — |
The compensation philosophy is to attract and retain talented and dedicated executives who work to achieve the Company's desired business direction, strategy, and performance, tying annual and long-term cash and equity incentives to specified performance objectives that increase stockholder value, while being competitive in the marketplace and cost-effective.
| CEO STI target (% of salary) | — |
|---|---|
| CEO LTI target (% of salary) | — |
| Independent consultant | None (no third-party compensation consultant has been engaged; internally generated peer group survey used instead) |
| Clawback policy | true |
| Anti-hedging | true |
| Anti-pledging | true |
| Meeting year | Meeting date | For | Against | Abstain | Support | Outcome |
|---|---|---|---|---|---|---|
| 2026 | 2026-06-18 | 446,238,170 | 17,487,326 | 413,667 | 96.23% | Passed |
| 2025 | 2025-04-23 | 439,260,125 | 10,995,027 | 513,047 | 97.56% | Passed |
| 2024 | 2024-03-28 | 431,121,613 | 13,954,192 | 1,522,265 | 96.86% | Passed |
| 2023 | 2023-06-22 | 437,636,656 | 14,823,803 | 1,085,003 | 96.72% | Passed |
| 2022 | 2022-07-14 | 402,336,412 | 28,153,806 | 936,566 | 93.46% | Passed |
| 2021 | 2021-06-24 | 407,430,454 | 22,479,703 | 1,744,347 | 94.77% | Passed |
Rows are labeled by annual-meeting year, with the meeting date beside each; the vote held in a given year acts on the prior fiscal year's compensation.
| Meeting year | Meeting date | Approval — company's computation |
|---|---|---|
| 2026 | 2026-06-18 | 96.23%a |
| 2025 | 2025-04-23 | 97.56%b |
| 2024 | 2024-03-28 | 96.86%c |
a. Voting standard not stated in the filing.
b. Approved under the standard stated in the filing — “Shares of our stock represented by proxies that reflect abstentions will be counted for the purpose of determining the existence of a quorum at the Annual Meeting, but will have no effect on the election of directors, the Say on Pay proposal, or the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2025.”.
c. Approved under the standard stated in the filing — “Shares of our stock represented by proxies that reflect abstentions will be counted for the purpose of determining the existence of a quorum at the Annual Meeting, but will have no effect on the approval of the election of directors, the Charter Amendment proposal, the Say on Pay proposal, or the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2024 .”.
Approval percentages are the company's own reported computations under its own stated standard, not recomputed by Velarion. Where a company does not state a standard, none is assumed.
| Ratio (CEO : median employee) | 42 : 1 |
|---|---|
| CEO total compensation | $1,854,000 |
| Median employee compensation | $44,252 |
| Director | Cash fees | Stock awards | Option awards | Non-equity incentive | All other | Total |
|---|---|---|---|---|---|---|
| Richard C. Pfenniger JrIndependent · Lead Independent Director · Audit (Chair) · Succession (Chair) | $70,000 | $58,200 | $0 | — | $0 | $128,200 |
| Richard C. Pfenniger, JrIndependent · Lead Independent Director · Audit (Chair) · Succession (Chair) | 70,000 | 0 | 58,200 | 0 | 0 | 128,200 |
| Prem A. Lachman, M.DIndependent · Audit · Compensation · Corporate Governance and Nominating · Independent Investment (Chair) | 60,000 | 29,100 | 0 | — | 0 | 89,100 |
| Richard M. Krasno, Ph.DIndependent · Compensation (Chair) · Audit · Independent Investment · Succession · Departed during FY | 60,000 | 29,100 | 0 | — | 0 | 89,100 |
| John A. PaganelliIndependent · Audit · Corporate Governance and Nominating (Chair) · Independent Investment · Succession | 52,500 | 29,100 | 0 | — | 0 | 81,600 |
| Roger J. Medel, M.DIndependent · Compensation · Corporate Governance and Nominating | 37,500 | 29,100 | 0 | — | 0 | 66,600 |
| Alice Lin-Tsing Yu, M.D., Ph.DIndependent | 30,000 | 29,100 | 0 | — | 0 | 59,100 |
| Phillip Frost, M.DEmployee director · Board Chair | 0 | 0 | 0 | — | 0 | 0 |
| Steven D. RubinEmployee director | 0 | 0 | 0 | — | 0 | 0 |
| Subbarao V. Uppaluri, Ph.DIndependent · Compensation (Chair) · Newly elected | 0 | 0 | 0 | — | 0 | 0 |
| Gary J. Nabel, M.D., Ph.DEmployee director | 0 | 0 | 0 | — | 0 | 0 |
| Elias A. Zerhouni, M.DEmployee director | 0 | 0 | 0 | — | 0 | 0 |
| Jane H. Hsiao, Ph.D., MBAEmployee director | 0 | 0 | 0 | — | 0 | 0 |
| Annual cash retainer | $30,000 |
|---|---|
| Annual equity retainer | — |
| Per board meeting fee | — |
| Committee chair fees (audit / comp / nom-gov) | 7,500 / 7,500 |
| Stock ownership guideline | — |
| Component | FY2025 |
|---|---|
| Cash retainers and fees | $380,000 |
| Equity awards (grant-date value) | $203,700 |
| All other compensation | $0 |
| Total cost of the board | $583,700 |
Computed as the sum of the director compensation table rows above; inputs and formula shown in the register.
Most recent fiscal-year chief executive compensation at each disclosed peer, taken from that company's own proxy statement.
| Rank | Company | FY | Chief executive | Salary | Stock awards | Option awards | Non-equity incentive | Total |
|---|---|---|---|---|---|---|---|---|
| 1 | OPKO Health, Inc. | 2025 | Phillip Frost | $960,000 | $0 | $400,000 | — | $1,854,000 |
Each peer's compensation is from its most recently filed proxy; fiscal years differ by company. Each peer's figures come from its own filings; the subject company is highlighted. Peers whose chief executive compensation is outside our coverage universe are stated as such, never left blank.
Answers are drawn only from the figures disclosed in this brief and cited to their location in the source filing. Where a figure required for an answer is not disclosed, that is stated rather than estimated.
Each figure's location is given both for the eye (section · page · table · row · column) and for a script (table/row/column index and exact character span in the filed document). Any figure can be independently confirmed against the source.
| # | Supports | Document | Filed | Accession | Location in document |
|---|---|---|---|---|---|
| 1 | Section 01, Phillip Frost | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Summary Compensation Table for 2023-”. As printed: 1,854,000. Filing ↗machine: t21 · r4 · c25 · span 941666–941675 |
| 2 | Section 01, Elias Zerhouni | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Summary Compensation Table for 2023-”. As printed: 1,764,000. Filing ↗machine: t21 · r12 · c25 · span 1012777–1012786 |
| 3 | Section 01, Jane Hsiao | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Summary Compensation Table for 2023-”. As printed: 1,764,000. Filing ↗machine: t21 · r8 · c25 · span 977235–977244 |
| 4 | Section 01, Steven Rubin | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Summary Compensation Table for 2023-”. As printed: 1,574,000. Filing ↗machine: t21 · r16 · c25 · span 1048297–1048306 |
| 5 | Section 01, Adam Logal | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Summary Compensation Table for 2023-”. As printed: 1,539,000. Filing ↗machine: t21 · r20 · c25 · span 1083868–1083877 |
| 6 | Section 03, Phillip Frost OPTION | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r4 · c17 · span 938915–938922 |
| 7 | Section 03, Elias Zerhouni OPTION | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r12 · c17 · span 1010026–1010033 |
| 8 | Section 03, Steven Rubin OPTION | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r16 · c17 · span 1045546–1045553 |
| 9 | Section 03, Adam Logal OPTION | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r20 · c17 · span 1081117–1081124 |
| 10 | Section 03, Jane Hsiao OPTION | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “EXECUTIVE COMPENSATION” · grants of plan-based awards table. Filing ↗machine: t21 · r8 · c17 · span 974484–974491 |
| 11 | Section 07, pay ratio | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “CEO Pay Ratio”. As printed: 42 : 1. Filing ↗machine: span 1630807–1630809 |
| 12 | Section 08, Richard C. Pfenniger Jr | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 128,200. Filing ↗machine: t15 · r10 · c27 · span 624113–624120 |
| 13 | Section 08, Richard C. Pfenniger, Jr | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 128,200. Filing ↗machine: t15 · r10 · c27 · span 624113–624120 |
| 14 | Section 08, Prem A. Lachman, M.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 89,100. Filing ↗machine: t15 · r8 · c27 · span 603866–603872 |
| 15 | Section 08, Richard M. Krasno, Ph.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 89,100. Filing ↗machine: t15 · r7 · c27 · span 593744–593750 |
| 16 | Section 08, John A. Paganelli | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 81,600. Filing ↗machine: t15 · r11 · c27 · span 634232–634238 |
| 17 | Section 08, Roger J. Medel, M.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 66,600. Filing ↗machine: t15 · r9 · c27 · span 613987–613993 |
| 18 | Section 08, Alice Lin-Tsing Yu, M.D., Ph.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 59,100. Filing ↗machine: t15 · r12 · c27 · span 644364–644370 |
| 19 | Section 08, Phillip Frost, M.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 20 | Section 08, Steven D. Rubin | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 21 | Section 08, Subbarao V. Uppaluri, Ph.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 22 | Section 08, Gary J. Nabel, M.D., Ph.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 23 | Section 08, Elias A. Zerhouni, M.D | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 24 | Section 08, Jane H. Hsiao, Ph.D., MBA | DEF 14A | 2026-04-30 | 0001193125-26-197120 | Section “Director Compensation”. As printed: 0. Filing ↗ |
| 25 | Section 02, John A. Paganelli 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277744 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 26 | Section 02, Alice Lin-Tsing Yu 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277731 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 27 | Section 02, Richard C. Pfenniger Jr 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277740 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 28 | Section 02, Subbarao Uppaluri V 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277734 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 29 | Section 02, Roger Medel Md 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277747 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 30 | Section 02, Prem A. Lachman 2026-06-18 | Form 4 | 2026-06-22 | 0001193125-26-277749 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 31 | Section 02, Adam Logal 2026-07-24 | Form 4 | 2026-07-28 | 0001193125-26-321055 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 32 | Section 02, Steven D. Rubin 2026-07-24 | Form 4 | 2026-07-28 | 0001193125-26-321041 | Insider equity transaction reported since the proxy statement. Filing ↗ |
| 33 | Section 06, 2026 vote | Form 8-K | 2026-06-18 | 0001193125-26-275818 | Item 5.07 · say-on-pay result. As reported: 96.23% (votes for as printed: 446,238,170). Filing ↗ |
| 34 | Section 06, 2025 vote | Form 8-K | 2025-04-23 | 0001437749-25-012806 | Item 5.07 · say-on-pay result. As reported: 97.56% (votes for as printed: 439,260,125). Filing ↗ |
| 35 | Section 06, 2024 vote | Form 8-K | 2024-03-29 | 0001437749-24-010069 | Item 5.07 · say-on-pay result. As reported: 96.86% (votes for as printed: 431,121,613.12). Filing ↗ |
| 36 | Section 01 trend, Δ column (computed) | Computed | — | computed | Δ = current-FY total − prior-FY total per named officer.machine: formula: Δ = FY(n) − FY(n−1) |
| 37 | Section 03b vehicle mix (computed) | Computed | — | computed | RSU / PSU / Options grant-date fair values summed per officer from the grants table; % performance-vested = PSU ÷ (RSU+PSU+Options).machine: formula: sums + PSU ratio |
| 38 | Section 09b board cost (computed) | Computed | — | computed | Cash 380,000 + equity 203,700 + all other 0 = 583,700, summed across the director compensation table rows.machine: formula: Σ = 583,700 |
| 39 | OPKO Health, Inc. (subject), Section 10b CEO total | DEF 14A | 2026-04-30 | 0001193125-26-197120 | CEO total compensation as printed in OPKO Health, Inc.'s own proxy. As printed: 1,854,000. Filing ↗machine: t21 · r4 · c25 · span 941666–941675 |