Chief Medical Officer · Spyre Therapeutics, Inc. (SYRE)

Sheldon Sloan

A named executive officer of Spyre Therapeutics in every fiscal year CompBrief holds from FY2024 to FY2025. Every figure below is printed as the company filed it and cited to the filing it came from.

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Total disclosed compensation, FY2025

$2,211,805

FY2024: $9,388,740

2nd of 4 named executive officers at Spyre Therapeutics by FY2025 total.

4 named officers on file for Spyre Therapeutics, FY2025

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What this number hides

The filing gives the total. Spyre Therapeutics’s full Executive Compensation Report gives every award, the disclosed peer set and what the total leaves out — the pair adds the board’s.

Compensation figures as of the proxy filed April 10, 2026 (DEF 14A). Insider transactions since that proxy, current to 2026-11-07.

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Sheldon Sloan compensation by year

Spyre Therapeutics Summary Compensation Table · all 2 fiscal years held
In US dollars, as Spyre Therapeutics reports it. Most recent year shaded. Totals are the company’s disclosed totals.
ComponentFY2024FY2025
Salary$124,000$503,000
Bonus$120,000$0
Stock awards$0$0
Option awards$9,075,480$1,433,245
Non-equity incentive$59,500$261,560
Pension and deferred compensation$0$0
All other$9,760$14,000
Total$9,388,740$2,211,805

Each year as stated in that year's proxy. A dash means the company reported no figure in that column. Source: Spyre Therapeutics, Inc. DEF 14A filed April 10, 2026, accession 0001636282-26-000039, and prior-year filings. Open the filing on EDGAR.

How this page was built: the Spyre Therapeutics, Inc. filed document, accession 0001636282-26-000039. Every figure is read from that document and cited to the page and table it appears in. Filed April 10, 2026.

$9.4M
$2.2M
FY24
FY25
SalaryBonusNon-equity incentiveOption awardsAll other

Equity holdings

unvested awards at FY2025 year-end
TypeUnvested unitsValue at year-endExercise price
Option283,334—$27.46
Option73,615—$21.66

Per the Outstanding Equity Awards at Fiscal Year-End table in Spyre Therapeutics, Inc.'s FY2025 proxy; value at the fiscal year-end close, as the company printed it.

Insider transactions since the last proxy

16 Form 4 lines since the FY2025 proxy (filed April 10, 2026)
current to 2026-11-07 · updated nightly
DateTransactionPlanSharesPriceHeld after
2026-07-01Sale10b5-11,834$88.340
2026-07-01Exercise or conversion derivative10b5-18,334$0.00305,000
2026-07-01Exercise or conversion10b5-18,334$27.468,334
2026-07-01Sale10b5-16,500$87.521,834
2026-06-03Exercise or conversion derivative10b5-18,333$0.00313,334
2026-06-03Exercise or conversion10b5-18,333$27.468,333
2026-06-03Sale10b5-18,333$75.000
2026-05-01Sale10b5-119,656$70.6137,371

The 8 most recent of 16 lines, each as reported on the Form 4. "10b5-1" marks a trade the filing reports under a pre-arranged trading plan. View every Form 4 filing on EDGAR →

Change-in-control & termination

estimated payments Spyre Therapeutics discloses, by trigger · FY2025
TriggerCash severanceAccelerated equityBenefits continuationTotal as disclosed
Change in control, no termination$0$0$0$0
Involuntary termination without cause$578,450$0$0$578,450
Change in control and involuntary termination$704,200$2,318,797$0$3,022,997
Death$0$2,318,797$0$2,318,797
Disability$0$2,318,797$0$2,318,797

Per the Potential Payments Upon Termination or Change in Control table in Spyre Therapeutics, Inc.'s FY2025 proxy. Estimates as the company printed them; a dash means it printed no figure.

Spyre Therapeutics’s named executive officers, FY2025

as the company reported each
Named executive officerRoleFY2025 total
Cameron TurtleChief Executive Officer$6,707,361
Sheldon Sloan · this pageChief Medical Officer$2,211,805
Heidy King-JonesChief Legal Officer and Corporate Secretary$2,192,045
Scott BurrowsChief Financial Officer$2,192,045

The full Spyre Therapeutics compensation record

free company brief

This page is one person within Spyre Therapeutics's record. The company brief lists every named executive, each linking to their own page.

Peer companies

named in the Spyre Therapeutics proxy · each links to its own free brief

Compensation, the day it’s disclosed

The CompBrief Daily Digest lists the newest executive and director compensation disclosures as companies file them. Or order Spyre Therapeutics's full Executive Compensation Report with peer benchmarking.

How this record is built

Every figure on this page is one figure from a public SEC filing, printed as the filing states it and cited to the document. Compensation totals are Spyre Therapeutics's own disclosed totals, not summed by Velarion. Insider transactions are read from Form 4 filings and cover every line filed since the most recent proxy. Nothing is estimated by Velarion; where the company does not disclose a value the cell reads "—", and a section appears only where the company discloses the data. Corrections: records@velarion.ai.

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Sheldon Sloan's compensation dossier