Velarion · Company Intelligence
Compensation Brief
Fiscal year 2025 · Filings through 2026-04-21

OnKure Therapeutics, Inc. (OKUR)

CEO Nicholas Saccomano was paid $1,467,934 in fiscal year 2025, ↓ down 84.6% from fiscal year 2024 (SEC filing 0001140361-26-015903 ↗): executive and director compensation, incentive-plan design, equity activity, and governance — every figure in this brief is traceable to its exact location in the company’s SEC filing — the document, the section, the page, and the table, linked directly.

$1,467,934 ↓
Nicholas Saccomano total, FY2025
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CEO pay percentile vs peers
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CEO-to-median pay ratio
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Say-on-pay support, latest vote

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Sample answer — “What is the CEO’s total compensation?”
- Nicholas Saccomano (President and Chief Executive Officer), FY2025 total compensation $1,467,934 (base salary $600,000) [exec_comp, SEC accession 0001140361-26-015903, filed 2026-04-21]

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OKUR's next annual pay disclosure, estimated April 26, 2027.est. Filing ↗

01

Summary Compensation Table — fiscal year 2025

Named executive officerSalaryBonusStock awardsOption awardsNon-equity incentivePension / NQDCAll otherTotal
Nicholas Saccomano$600,000$0$0$609,934$247,500$0$10,500$1,467,934
President and Chief Executive Officer
Jason Leverone444,00000304,967133,200014,000896,167
Chief Financial Officer
Samuel Agresta482,00000211,131144,600014,000851,731
Chief Medical Officer

A dash means the company reported no figure in that column; 0 means it reported zero. Figures are as printed in the filing, without adjustment.

Three-year trend — total compensation per named executive

Named executive officerFY2025 totalFY2024 totalFY2023 totalΔ FY2024→2025
Nicholas Saccomano$1,467,934$9,515,165—↓ −8,047,231
Jason Leverone896,1672,678,570—↓ −1,782,403
Samuel Agresta851,7312,841,068—↓ −1,989,337

Prior-year totals as disclosed in the corresponding proxy; deltas are computed values with the derivation shown in the register.

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Companies that benchmark against OKUR
No companies currently name OKUR as a compensation peer in their most recent disclosure.

This is the complete answer, not a partial one — the list is never padded.

01c

Board of directors

One page per director: the seat, the committees and the fee table, read for one person at a time.

DirectorRoleFY2025 total
Andrew Phillips, Ph.DIndependent Director$103,794
Dr. SaccomanoDirector—
Edward MathersIndependent Director$61,292
Isaac Manke, Ph.DIndependent Director$76,791
Liam Ratcliffe, Ph.DIndependent Director—
Michael GreyIndependent Director$56,294
R. Michael CarruthersIndependent Director$71,294
Valerie M. Jansen, M.D., Ph.DIndependent Director$60,294
02

Equity transactions since the proxy statement was filed

No insider equity transactions reported since the proxy statement.

03

Grants of plan-based awards — fiscal year 2025

ExecutiveAwardGrant dateThresholdTargetGrantedMaximumGrant-date fair value
Jason Leverone, C.P.A.OPTION———65,000—$304,967
Samuel Agresta, M.D.OPTION———45,000—211,131
03b

Vehicle mix — grant-date fair value by award type

Named executive officerTime-vested (RSU)Performance-vested (PSU)Options / SARs% performance-vested
Jason Leverone, C.P.A.$0$0$304,9670.0%
Samuel Agresta, M.D.00211,1310.0%

% performance-vested = PSU grant-date fair value ÷ (RSU + PSU + Options), a computed value with the derivation shown in the register.

04

Outstanding equity awards at fiscal year-end 2025

ExecutiveAwardShares unvestedExercise priceMarket value unvested
SaccomanoOption49513.99—
Samuel AgrestaOption80,29818.2—
Jason LeveroneRSU5,105—14,805
SaccomanoRSU1,424—4,130
Samuel AgrestaOption34,6885.19—
SaccomanoOption331,36418.2—
SaccomanoOption100,2095.19—
Jason LeveroneOption12121.2—
Jason LeveroneOption1,77413.99—
Jason LeveroneOption79,81818.2—
Jason LeveroneOption50,1055.19—
Samuel AgrestaOption10,06913.99—
05

Incentive-plan design — the Compensation Discussion & Analysis

The Board and Compensation Committee recognize the importance of base salary as a fixed source of income to attract and retain NEOs, while using annual bonuses and equity awards to align executive interests with stockholder value creation.

CEO STI target (% of salary)—
CEO LTI target (% of salary)—
Independent consultantAlpine Rewards, LLC
Clawback policytrue
Anti-hedgingtrue
Anti-pledgingtrue
08

Director compensation — fiscal year 2025

DirectorCash feesStock awardsOption awardsNon-equity incentiveAll otherTotal
Andrew Phillips, Ph.DIndependent · Audit · Compensation (Chair) · Nominating and Corporate Governance (Chair)$87,500$0$16,294—$0$103,794
Isaac Manke, Ph.DIndependent60,497016,294—076,791
R. Michael CarruthersIndependent · Audit (Chair)55,000016,294—071,294
Edward MathersIndependent · Audit · Compensation44,998016,294—061,292
Valerie M. Jansen, M.D., Ph.DIndependent · Nominating and Corporate Governance44,000016,294—060,294
Michael GreyIndependent40,000016,294—056,294
Nicholas SaccomanoEmployee director—————0
Liam Ratcliffe, Ph.DIndependent · Newly elected000——0
Dr. SaccomanoEmployee director—————0
09

Board fee structure and ownership guideline

Annual cash retainer$40,000
Annual equity retainer—
Per board meeting fee—
Committee chair fees (audit / comp / nom-gov)15,000 / 5,000 / 8,000
Stock ownership guideline—
09b

Total cost of the board

ComponentFY2025
Cash retainers and fees$331,995
Equity awards (grant-date value)$0
All other compensation$0
Total cost of the board$331,995

Computed as the sum of the director compensation table rows above; inputs and formula shown in the register.

10b

Chief executive pay against the peer group

Most recent fiscal-year chief executive compensation at each disclosed peer, taken from that company's own proxy statement.

RankCompanyFYChief executiveSalaryStock awardsOption awardsNon-equity incentiveTotal
1OnKure Therapeutics, Inc.2025Nicholas Saccomano$600,000$0$609,934$247,500$1,467,934

Each peer's compensation is from its most recently filed proxy; fiscal years differ by company. Each peer's figures come from its own filings; the subject company is highlighted. Peers whose chief executive compensation is outside our coverage universe are stated as such, never left blank.

10d

Frequently asked questions

Who was the highest-paid executive at OnKure Therapeutics, Inc. in fiscal 2025?
As disclosed, Nicholas Saccomano (President and Chief Executive Officer) was the highest-paid executive at OnKure Therapeutics, Inc. in fiscal 2025, with total compensation of $1,467,934.
How much does OnKure Therapeutics, Inc. spend in total on board compensation for fiscal 2025?
As disclosed, OnKure Therapeutics, Inc. reported total board compensation of $331,995 for fiscal 2025.

Answers are drawn only from the figures disclosed in this brief and cited to their location in the source filing. Where a figure required for an answer is not disclosed, that is stated rather than estimated.

11

Source register

Each figure is listed with the filing it comes from, where it appears in that filing, and the value as printed. Any figure can be independently confirmed against the source.

#SupportsDocumentFiledAccessionLocation in document
1Section 01, Nicholas SaccomanoDEF 14A2026-04-210001140361-26-015903Section “Executive Compensation”. As printed: 1,467,934. View filing ↗
2Section 01, Jason LeveroneDEF 14A2026-04-210001140361-26-015903Section “Executive Compensation”. As printed: 896,167. View filing ↗
3Section 01, Samuel AgrestaDEF 14A2026-04-210001140361-26-015903Section “Executive Compensation”. As printed: 851,731. View filing ↗
4Section 03, Jason Leverone, C.P.A. OPTIONDEF 14A2026-04-210001140361-26-015903Section “Executive Compensation” · grants of plan-based awards table. View filing ↗
5Section 03, Samuel Agresta, M.D. OPTIONDEF 14A2026-04-210001140361-26-015903Section “Executive Compensation” · grants of plan-based awards table. View filing ↗
6Section 08, Andrew Phillips, Ph.DDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 103,794. View filing ↗
7Section 08, Isaac Manke, Ph.DDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 76,791. View filing ↗
8Section 08, R. Michael CarruthersDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 71,294. View filing ↗
9Section 08, Edward MathersDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 61,292. View filing ↗
10Section 08, Valerie M. Jansen, M.D., Ph.DDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 60,294. View filing ↗
11Section 08, Michael GreyDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 56,294. View filing ↗
12Section 08, Nicholas SaccomanoDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 0. View filing ↗
13Section 08, Liam Ratcliffe, Ph.DDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 0. View filing ↗
14Section 08, Dr. SaccomanoDEF 14A2026-04-210001140361-26-015903Section “Director Compensation”. As printed: 0. View filing ↗
15Section 01 trend, Δ column (computed)Computed——Δ = current-FY total − prior-FY total per named officer.
16Section 03b vehicle mix (computed)Computed——RSU / PSU / Options grant-date fair values summed per officer from the grants table; % performance-vested = PSU ÷ (RSU+PSU+Options).
17Section 09b board cost (computed)Computed——Cash 331,995 + equity 0 + all other 0 = 331,995, summed across the director compensation table rows.
18OnKure Therapeutics, Inc. (subject), Section 10b CEO totalDEF 14A2026-04-210001140361-26-015903CEO total compensation as printed in OnKure Therapeutics, Inc.'s own proxy. As printed: 1,467,934. View filing ↗